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About Diabetes and Exercise
There are two main types of diabetes, type I and type II. Type I diabetes is characterized by the pancreas making too little or no insulin. An individual with diabetes type I will have to inject insulin throughout the day in order to control...
Diabetes: African Americans Deadly Foe
Diabetes is having a devastating effect on the African American community. Diabetes is the fifth leading cause of death in African Americans and their death rates are twenty seven percent higher than whites.
Over 2.8 million African...
Diabetes, Impotence, and Viagra
25 Aug 2005
Approximately 8.7 million, or 8.7% of all men over the age of 20 in the United States have diabetes. The most life-threatening consequences of diabetes are heart disease and stroke, which strike people with diabetes more than twice...
Diabetes, Recognizing the Signs, and Symptoms
Do you find yourself going to the bathroom more than usual? Are you unusually hungry or thirsty? Is fatigue a normal, everyday feeling? Does spontaneous, blurred vision interfere with you daily life? If this sounds like you, you may have Diabetes....
Raising Happy Diabetic Kids Part II Help Yor Child Develop Self-Relience
This is the second article in a series I am writing about how to raise happy diabetic children. You can find the first article titled Help Your Child Develope Self-Confidence in our article archives. Sometimes the phrase "happy diabetic kids"...
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Combination of Thiazide-Type Diuretic and Beta-Blocker may Cause Diabetes
Clinical Question: In patients with hypertension is it safe to combine thiazide-type diuretic and beta-blocker?
Bottom Line: Studies suggest that the routine combined use of a thiazide with a beta-blocker should be questioned in the early management of hypertension, particularly in patients who are at increased risk of developing new-onset diabetes. In such patients, the increased risk of developing diabetes may exceed the benefit of blood pressure lowering.
Reference: J Hypertens. 2005 Oct;23(10):1777-1781
Study Design: Retrieve randomized control trials and meta-analysis
Synopsis: Recently published trials addressing the pharmacological management of hypertension have reported an increase in new-onset diabetes mellitus when comparing certain older and newer treatment regimens. Thiazide-type diuretics (thiazides) and beta-blockers have been individually implicated, but these drugs are frequently combined, and the magnitude of risk associated with their combined use has not been quantified. So randomized control trials were retrieved that: (i) featured stepped treatment to manage hypertension; (ii) compared initial treatment using a thiazide or beta-blocker (older drug) with an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or calcium antagonist (newer drug); (iii) assessed cardiovascular outcomes; (iv) reported new-onset diabetes; and (v) provided at least 1-year follow-up. A meta-analysis of available trials indicated that patients exposed to treatment regimens combining thiazides and beta-blockers are at greater risk of developing diabetes than regimens avoiding this combination of drugs (risk ratio for alternative therapy 0.81, 95% confidence interval 0.77-0.86). Current data cannot inform reliably about the risks associated with individual older drugs because of similar overall exposures in patients starting on newer and older drugs.
About the Author
A Certified Family Physician of the Philippine Academy of Family Physician and continue to complete the requirements for Continuing Medical Education in Family Practice. Also a member of the Philippine Medical Informatics Society, Philippine Occupational Health and Safety Inc., and Pangasinan Medical Society.
Faculty Department of Physiology (Medicine) Lyseum- Northwestern University, Dagupan, Pangasinan, Faculty Medical Informatics Lyseu
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